慢性腎病(Chronic kidney disease，CKD)目前成為了一個(gè)主要的公共衛(wèi)生問(wèn)題，有越來(lái)越多的成年人患有CKD。多年來(lái)，針對(duì)這種疾病進(jìn)行了大量研究，但仍需要改進(jìn)治療方法并識(shí)別和/或預(yù)測(cè)患者預(yù)后結(jié)果。已經(jīng)確定在腎臟疾病中起重要作用的一種蛋白質(zhì)是腎損傷分子-1 (KIM-1)。KIM-1是一種30KDa的I型膜蛋白，具有包含免疫球蛋白(Ig)和高度O-糖基化粘蛋白亞結(jié)構(gòu)域以及多個(gè)N-糖基化位點(diǎn)的胞外域。它是損傷腎臟近端小管中最高度上調(diào)的蛋白質(zhì)。它在正常腎臟中以非常低的水平存在，但會(huì)在損傷期間上調(diào)，在多種疾病的尿液中可檢測(cè)到。KIM-1可能是腎損傷的生物標(biāo)志物，這表明它在各種腎臟疾病中具有重要意義，例如慢性腎臟疾病，以及急性腎小管壞死和急性腎衰竭。

Enzo Life Sciences提供的KIM-1 (human) ELISA kit可定量檢測(cè)人尿液樣本中的早期腎損傷生物標(biāo)志物KIM-1，超高靈敏度，可檢測(cè)低至1.279 pg/ml的KIM-1。

產(chǎn)品信息

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部分產(chǎn)品文獻(xiàn)引用

1. Identification of Pre-Renal and Intrinsic Acute Kidney Injury by Anamnestic and Biochemical Criteria: Distinct Association with Urinary Injury Biomarke: S.M. Sancho-Martínez, et al.; Int. J. Mol. Sci. 24, 1826 (2023)

2. Early Diagnosis of Kidney Damage Associated with Tobacco Use: Preventive Application: J. Tascón, et al.; J. Pers. Med. 12, 1032 (2022)

3. The effect of interval and continuous work on markers of acute kidney injury in a hot environment: J. Houck, et al.; Eur. J. Appl. Physiol. 122, 2437 (2022)

4. The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males: T. Tominaga, et al.; Antioxidants (Basel) 10, 866 (2021), Application(s): KIM-1 quantification on human urine and plasma samples

5. Biomarkers in the prediction of contrast media induced nephropathy – the BITCOIN study: F.S. Seibert, et al.; PLoS One 15, e0234921 (2020)

6. Designing new diagnostic systems for the early detection of tobacco-associated chronic renal damage in patients of a primary care centre in Salamanca, Spain: an observational, prospective study protocol: M. Prieto, et al.; BMJ Open 10, e032918 (2020)

7. Quercetin, a promising clinical candidate for the prevention of contrast-induced nephropathy: L. Vicente-Vicente, et al.; Int. J. Mol. Sci. 20, 4961 (2019), Application(s): ELISA using human urine

8. Prognostic Value of Urinary Calprotectin, NGAL and KIM-1 in Chronic Kidney Disease: F.S. Seibert, et al.; Kidney Blood Press Res. 43, 1255 (2018)

9. Urinary Biomarkers in the Prediction of Prognosis and Treatment Response in IgA Nephropathy: J. Neuhaus, et al.; Kidney Blood Press Res. 43, 1563 (2018)

10. Hepatic ischemia/reperfusion injury associates with acute kidney injury in liver transplantation: prospective cohort study: I. Jochmans, et al.; Liver Transpl. 23, 634 (2017), Application(s): ELISA using human urine

11. Urinary calprotectin, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin for the prediction of adverse outcome in pediatric acute kidney injury: J.H. Westhoff, et al.; Eur. J. Pediatr. 176, 745 (2017), Application(s): ELISA using human urine

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